Abstract: This paper has studied and compared three methods of determi nation of cardiovascular drug, Nitrendipine: Cyanide selective electrode method, single sweep polarography and UV-spectrophotometric method. The reproducibility and precision of each method can reach the level of analysis, Cyanide selective electrode method displays a Nernstian response in the range of 1×10^-3～5×10^-6 mol/L and its slope is about 50 mV/pC. Single-sweep polarography has linear range in 10^-3～10^-6mol/L, and UV-spectrophotometric method displays linear range in 10^-4～10^-6mol/L. All of the three methods can determine the contents of nitrendipine. Among these methods, the cyanide selective electrode method can determine the effective ingredient of nitrendipine. It is predicted that the method can find some applications in the study of pharmacology of nitrendipine.