骨碎补中的两个新酚酸类化合物

梁永红 叶敏 张灵芝 李卉芳 韩健 王宝荣 果德安

骨碎补中的两个新酚酸类化合物

梁永红叶敏张灵芝李卉芳韩健王宝荣果德安

Two new phenolic acids from Drynariae Rhizoma

LIANG Yong-Gong

摘要

摘要:
为了研究骨碎补的化学成分, 采用硅胶、ODS、Sephadex LH-20柱色谱及半制备高效液相色谱等技术, 从中药骨碎补的70% 乙醇提取物中分离得到9个酚酸类化合物。其结构经¹H NMR、¹³C NMR、2D NMR、HR-ESI-MS等谱学方法分别鉴定为4, 4'-dihydroxy-3, 3'-imino-di-benzoic acid (1)、原儿茶酸 (protocatechuic acid, 2)、没食子酸 (gallic acid, 3)、对羟基苯甲酸 (p-hydroxybenzoic acid, 4)、咖啡酸 (E)-caffeic acid, 5、ethyl trans- 3, 4-dihydroxycinnamate (6)、咖啡酸4-O-β-D-葡萄糖苷 (caffeic acid 4-O-β-D-glucopyranoside, 7)、对-香豆酸4-O- β-D-葡萄糖苷 (p-coumaric acid 4-O-β-D-glucopyranoside, 8) 和23(S)-12-O-caffeoyl-12-hydroxyllauric acid glycerol ester (9)。其中, 化合物1和9为新化合物, 化合物3、4、6为首次从槲蕨属植物中分离得到。

Abstract:
To study the chemical constituents of Drynariae Rhizoma, nine phenolic acids were isolated from a 70% ethanol extract by using a combination of various chromatographic techniques including column chromatography over silica gel, ODS, Sephadex LH-20, and semi-preparative HPLC. By spectroscopic techniques including ¹H NMR, ¹³C NMR, 2D NMR, and HR-ESI-MS, these compounds were identified as 4, 4'-dihydroxy-3, 3'-imino-di-benzoic acid (1), protocatechuic acid (2), gallic acid (3), p-hydroxybenzoic acid (4), (E)-caffeic acid (5), ethyl trans-3, 4-dihydroxycinnamate (6), caffeic acid 4-O-β-D-glucopyranoside (7), p-coumaric acid 4-O-β-D-glucopyranoside (8), and 23(S)-12-O-caffeoyl-12-hydroxyllauric acid glycerol ester (9), separately. Among them, 1 and 9 are new compounds, and 3, 4, and 6 were isolated from Drynaria species for the first time.

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