Abstract: Drug ion-selective electrodes made with hetero-poly anion as exchange site exhibit better performances than the respective electrodes of conventional tetraphenylboron type, yielding low detection limits and fast responses. Functions of propantheline, berberine, dibazol, thiamine, streptomycin, moroxydine, tetracycline, oxytetracycline, doxycycline, erythromycin, carbetapentane, benzydamine, tetramisole and trifluoperazine electrodes are reported. The electrodes can be used in potentiometric determinations of the respective drugs in aqueous solutions, urine and mixtue of water and organic solvents.