梁鸿, 赵玉英, 邱海蕴, 黄颉, 张如意. 北柴胡中新皂甙的结构鉴定J. 药学学报, 1998, 33(1): 37-41.
引用本文: 梁鸿, 赵玉英, 邱海蕴, 黄颉, 张如意. 北柴胡中新皂甙的结构鉴定J. 药学学报, 1998, 33(1): 37-41.
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Liang Hong, Zhao Yuying, Qiu Haiyun, Huang Jie , Zhang Ruyi, . A NEW SAIKOSAPONIN FROM BUPLEURUM CHINESE DC.J. Acta Pharmaceutica Sinica, 1998, 33(1): 37-41.
Citation: Liang Hong, Zhao Yuying, Qiu Haiyun, Huang Jie , Zhang Ruyi, . A NEW SAIKOSAPONIN FROM BUPLEURUM CHINESE DC.J. Acta Pharmaceutica Sinica, 1998, 33(1): 37-41.
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北柴胡中新皂甙的结构鉴定

A NEW SAIKOSAPONIN FROM BUPLEURUM CHINESE DC.

    摘要
  • 摘要: 从北柴胡(Bupleurum chinese DC.)根醇提液的正丁醇部分得到7个化合物,经鉴定分别为柴胡皂甙a(saikosaponina,1),柴胡皂甙d(saikosaponind,2),柴胡皂甙c(saikosaponinc,3),柴胡皂甙f(saikosaponinf,4),柴胡皂甙b3 (saikosaponin b3,5),柴胡皂甙b2(saikosaponin b2,6)和柴胡皂甙t(saikosaponint,7),化合物7为新化合物,用化学和波谱法确定其结构为3β,16β,28-三羟基-11-α-甲氧基-12-齐墩果烯-3-O-β-D-葡萄糖基-(1→3)-β-D-呋糖甙。化合物1～6均为首次自北柴胡中分离鉴定。

     

    Abstract: Bupleurum chinese DC. is a well-known and very important traditional Chinese drug. It is often used to treat common cold with fever, alternating chill and fever, the feeling of fullness and oppression in the chest. A new saikosaponin was isolated from Bupleurum chinese DC. and its structure was identified as 3β,16β,28-trihydroxy-11-α-methoxy-olean-12-ene-3-O-β-D-glucosyl-(1→3)-β-D-fucoside on the basis of chemical and spectral evidence. In addition, six known saikosaponins were isolated and characterized as saikosaponin a, saikosaponin d, saikosaponin c, saikosaponin f, saikosaponin b3 and saikosaponin b2. All these compounds were isolated from Bupleurum chinense DC. for the first time.

     

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