缪振春, 杜泽涵, 徐桂芬, 石庭森. 吡罗昔康与β-环糊精包合物结构的核磁共振研究J. 药学学报, 1988, 23(9): 682-687.
引用本文: 缪振春, 杜泽涵, 徐桂芬, 石庭森. 吡罗昔康与β-环糊精包合物结构的核磁共振研究J. 药学学报, 1988, 23(9): 682-687.
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ZC Miao, ZH Du, GF Xu , TS Shi, . A STRUCTURAL STUDY OF THE INCLUSION COMPOUND OF PIROXCAM WITH β-CYCLODEXTRIN BY NMRJ. Acta Pharmaceutica Sinica, 1988, 23(9): 682-687.
Citation: ZC Miao, ZH Du, GF Xu , TS Shi, . A STRUCTURAL STUDY OF THE INCLUSION COMPOUND OF PIROXCAM WITH β-CYCLODEXTRIN BY NMRJ. Acta Pharmaceutica Sinica, 1988, 23(9): 682-687.
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吡罗昔康与β-环糊精包合物结构的核磁共振研究

A STRUCTURAL STUDY OF THE INCLUSION COMPOUND OF PIROXCAM WITH β-CYCLODEXTRIN BY NMR

    摘要
  • 摘要: 本文采用1HNMR和二维NOE等方法研究了吡罗昔康与β-环糊精包合物的结构。化学位移变化和NOE的结果提示,在溶液中二者的摩尔比为1:1时,主要是药物的苯环部份包藏在β-环糊精的空腔内。

     

    Abstract: A structural study of the inclusion compound of piroxcam with β-cyclodextrin in aqueous solution was attempted by 1H-NMR, DQF-COSY and 2DNOE. The results of chemical shift changes and NOE suggests that when the molar ratio of piroxcam to β-cyclodextrin is one, the phenyl ring of piroxcam is predominantly included within the β-cyclodextrin cavity, forming a 1:1 inclusion compound.

     

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