Abstract: Nimodipine was shown to improve anisodine-induced impairments of active and passive avoidance responses, while nifedipine and vincamine increased passive avoidance response only in rats. The potency of nimodipine on amnesia was 100～200 and 1,000～2,000 times as large as nifedipine and vineamine respectively. Nimodipine was capable of antagonizing pentobarbital-induced impairment of learning in water maze and cycloheximide-elicited deficit of consolidation of memory in step down and step through tests in mice. However, nifedipine and vincamine did not show significant effect on the parameters mentioned above. Effects of the three cerebral vasodilators on alcohol-induced deficit of retrieval of mice were also studied in step down test. Good result was obtained with vincamine, but not with nimodipine and nifedipine.