Abstract: Anabasine hydrochloride is a muscle relaxant. A large dose of anabasine would cause respiratory depression or arrest. To antagonize the side reaction, we studied the effects of resibufogenin, (It is a central respiratory stimulant) and neostigminum on the respira tory depression caused by anabasine in rabbits. The results of comparative study in anesthetic and unanesthetized rabbits showed, that anabasine could inhibit the brain stem respiratory centre, and anesthetics enhance the effect mentioned Resibufogenin could effectively antagonize the central respiratory depression. Thus, the author suggests, that resibufogenin might be useful to treat the respiratory depression caused by anabasine in anesthetic patients.