冯闻铮, 亓平言, 周倜, 苗勇, 段训宝. 螺旋霉素在酸碱溶液中的降解动力学J. 药学学报, 1997, 32(12): 934-937.
引用本文: 冯闻铮, 亓平言, 周倜, 苗勇, 段训宝. 螺旋霉素在酸碱溶液中的降解动力学J. 药学学报, 1997, 32(12): 934-937.
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WZ Feng, PY Qi, T Zhou, Y Miao , XB Duan, . STUDY ON THE DEGRADATION KINETICS OF SPIRAMYCIN IN ACID AND ALKALINE SOLUTIONSJ. Acta Pharmaceutica Sinica, 1997, 32(12): 934-937.
Citation: WZ Feng, PY Qi, T Zhou, Y Miao , XB Duan, . STUDY ON THE DEGRADATION KINETICS OF SPIRAMYCIN IN ACID AND ALKALINE SOLUTIONSJ. Acta Pharmaceutica Sinica, 1997, 32(12): 934-937.
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螺旋霉素在酸碱溶液中的降解动力学

STUDY ON THE DEGRADATION KINETICS OF SPIRAMYCIN IN ACID AND ALKALINE SOLUTIONS

    摘要
  • 摘要: 研究了螺旋霉素(SPM)在酸碱条件下的降解规律和降解动力学,回归出降解动力学参数。实验证明,SPM在水溶液中的稳定范围为pH4.0～10.0。在pH<4.0和pH>10.0,特别是pH<2.8和pH>12.8的情况下,SPM在水溶液中发生严重的降解,因而大大地影响了SPM的收率。还利用文献数据对其在水中的溶解度进行了研究,求出了热力学参数。

     

    Abstract: Physical and chemical characteristics of spiramycin (SPM) were reviewed in this paper. The degradation rule and kinetics of SPM in acid and alkaline solutions were studied, and the kinetic parameters were calculated. The experimental results showed that the stable range of SPM in water is at pH 4.0～10.0. Degradation occurred seriously at pH<4.0 and pH>10.0, especially at pH<2.8 and pH>12.8. For this reason, the yield of SPM is greatly affected. The solubility in water was also studied by using reference data. The thermodynamical parameters were calculated. The results showed that the solution of SPM in water is exothermic. The solubility decreases as the temprature rises.

     

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