柱前手性衍生化反相高效液相色谱法拆分地佐西平对映异构体的研究

邱宗荫; 阳华学; 李惠芝; 赵华; 靳红卫

邱宗荫, 阳华学, 李惠芝, 赵华, 靳红卫. 柱前手性衍生化反相高效液相色谱法拆分地佐西平对映异构体的研究J. 药学学报, 1995, 30(6): 454-458.

引用本文:

邱宗荫, 阳华学, 李惠芝, 赵华, 靳红卫. 柱前手性衍生化反相高效液相色谱法拆分地佐西平对映异构体的研究J. 药学学报, 1995, 30(6): 454-458.

ZY Qiu, HX Yang, NZ Li, H Zhao , HW Jin, . RESOLUTION OF THE ENANTIOMERS OF DIZOCILPINE BY REVERSED PHASE HPLC AFTER DERIVATIZATION WITH GITCJ. Acta Pharmaceutica Sinica, 1995, 30(6): 454-458.

Citation:

ZY Qiu, HX Yang, NZ Li, H Zhao , HW Jin, . RESOLUTION OF THE ENANTIOMERS OF DIZOCILPINE BY REVERSED PHASE HPLC AFTER DERIVATIZATION WITH GITCJ. Acta Pharmaceutica Sinica, 1995, 30(6): 454-458.

柱前手性衍生化反相高效液相色谱法拆分地佐西平对映异构体的研究

RESOLUTION OF THE ENANTIOMERS OF DIZOCILPINE BY REVERSED PHASE HPLC AFTER DERIVATIZATION WITH GITC

摘要

摘要: 用乙酰葡萄糖异硫氰酸酯(GITC)作柱前手性衍生化试剂,以反相高效液相色谱法成功地拆分了地佐西平对映异构体。在此基础上建立了地佐西平对映异构体纯度和血药浓度测定方法。已用于测定右旋地佐西平的光学纯度和小鼠血药浓度。

Abstract: Dizocilpine :Enantioseparation;2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl isothiocyanate(GITC);Reversed phase HPLC

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