李惠芝, 赵华, 余瑜, 邱宗荫. GITC柱前手性衍生化HPLC测定吡喹胺光学异构体纯度J. 药学学报, 1993, 28(6): 450-454.
引用本文: 李惠芝, 赵华, 余瑜, 邱宗荫. GITC柱前手性衍生化HPLC测定吡喹胺光学异构体纯度J. 药学学报, 1993, 28(6): 450-454.
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HZ Li, H Zhao, Y Yu , ZY Qiu, . DETERMINATION OF THE OPTICAL PURITY OF PRAZIQUANAMINE BY REVERSED PHASE HPLC AFTER DERIVATIZATION WITH GITCJ. Acta Pharmaceutica Sinica, 1993, 28(6): 450-454.
Citation: HZ Li, H Zhao, Y Yu , ZY Qiu, . DETERMINATION OF THE OPTICAL PURITY OF PRAZIQUANAMINE BY REVERSED PHASE HPLC AFTER DERIVATIZATION WITH GITCJ. Acta Pharmaceutica Sinica, 1993, 28(6): 450-454.
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GITC柱前手性衍生化HPLC测定吡喹胺光学异构体纯度

DETERMINATION OF THE OPTICAL PURITY OF PRAZIQUANAMINE BY REVERSED PHASE HPLC AFTER DERIVATIZATION WITH GITC

    摘要
  • 摘要: 以乙酰葡萄糖异硫氰酸酯(GITC)作柱前手性衍生化试剂,用反相高效液相色谱法成功地拆分了吡喹胺(1,3,4,6,7,11b-六氢-2H吡嗪2,1-a并异喹啉-4-酮)光学异构体。在此基础上建立了测定吡喹胺光学异构体纯度的方法,并已用于d-和l-吡喹胺纯度的测定。

     

    Abstract: The enantiomers of praziquanamine were separated by reversed phase HPLC after derivatization with 2,3,4,6- tetra- O- acetyl- β-D- glucopyranosylisothiocyanate (GITC). The determination of the optical purity of praziquanamine was successfully achieved. This method was applied to the determination of the optical purity of d-and l-praziquanamines.

     

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