增塑剂及膜材比例对Eudragit L100/S100游离膜机械性能和透湿性的影响

The mechanical properties and moisture permeability of Eudragit L100/S100 free films affected by plasticizers and membrane materials ratio

摘要:
采用平面铸膜法制备对pH敏感、可用于结肠定位的Eudragit L100/S100游离膜, 并考察成膜湿度、增塑剂的种类与用量及膜材的比例对游离膜的影响。以膜的透湿性、机械性能为指标设计正交实验, 优选出最佳的成膜处方, 并研究其相关特性。结果表明, 以柠檬酸三乙酯为增塑剂且含量为30%时, 膜的机械性能和成膜性最好; 膜材比例变化对游离膜的机械性能和透湿性影响不大。通过调整增塑剂的种类、用量及Eudragit L100/S100配比, 可以制得符合结肠定位释放要求的游离膜。

Abstract:
The free membrane of Eudragit L100/S100 which is pH-sensitive, colon-specific was prepared by plane casting films. The film humidity, species and amount of plasticizers, the ratio of membrane material was investigated. The rate of membrane permeability and mechanical properties were used as indicators of orthogonal experiment, and its related properties were studied. The results show that the mechanical properties of the membrane and phragmoid capacity are the best when 30% TEC was used as plasticizer; the ratio of membrane material have little effect on the rate of membrane permeability and mechanical properties. By adjusting the species and amount of plasticizers, the ratio of Eudragit L100/S100, the free membrane which is colon-specific can be obtained.