李志田, 杨保津, 马广恩. 白花丹参化学成分的研究J. 药学学报, 1991, 26(3): 209-213.
引用本文: 李志田, 杨保津, 马广恩. 白花丹参化学成分的研究J. 药学学报, 1991, 26(3): 209-213.
ZT Li, BJ Yang , GE Ma, . CHEMICAL STUDIES OF SALVIA MILTIORRHIZA F.LBAJ. Acta Pharmaceutica Sinica, 1991, 26(3): 209-213.
Citation: ZT Li, BJ Yang , GE Ma, . CHEMICAL STUDIES OF SALVIA MILTIORRHIZA F.LBAJ. Acta Pharmaceutica Sinica, 1991, 26(3): 209-213.

白花丹参化学成分的研究

CHEMICAL STUDIES OF SALVIA MILTIORRHIZA F.LBA

  • 摘要: 从白花丹参(Salvia miltiorrhiza f.alba)中分离出14个二萜醌类化合物,其中2个为新化合物,由光谱分析推定为1,2,15,16-四氢丹参醌(Ⅰ)和丹参醛(Ⅱ);另一个化合物Ⅲ与R0-090680的结构相同。化合物Ⅰ和Ⅲ对淋巴白血病细胞P388均有较强的抑制作用。

     

    Abstract: Fourteen constituents were isolated from the roots of Salvia miltiorrhiza f. alba. Two of them were new compounds and were named 1, 2, 15, 16-tetrahydrotanshiquinone (Ⅰ) and tanshinaldehyde (Ⅱ). The others were identified as Ro-090680 (Ⅲ), dihydroisotanshone Ⅰ(Ⅳ), danshexinkun B(Ⅴ), miltirone (Ⅵ), nortanshinone (Ⅶ), hydroxytanshinone Ⅱ-A(Ⅷ), tanshinone Ⅰ(Ⅸ), dihydrotanshinone Ⅰ(Ⅹ), tanshinone Ⅱ-A(ⅩⅠ), cryptotanshinone (ⅩⅡ), methylenetanshiquinone (ⅩⅢ), methyltanshinonate (ⅩⅣ), Ⅰ and Ⅲ showed inhibitory activity against P388 Leukemia cell in vitro. Ⅲ was reported to be a potent inhibitor of rabbit platelet aggregation induced by collagen.

     

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