鄢立刚, 徐炳祥, 马振瀛, 朱艳静, 杨倩华. 7-取代-1-乙基(2-氟乙基)-6,8-二氟-1,4-二氢-4-氧喹啉-3-羧酸的合成及抗菌活性J. 药学学报, 1998, 33(5): 392-395.
引用本文: 鄢立刚, 徐炳祥, 马振瀛, 朱艳静, 杨倩华. 7-取代-1-乙基(2-氟乙基)-6,8-二氟-1,4-二氢-4-氧喹啉-3-羧酸的合成及抗菌活性J. 药学学报, 1998, 33(5): 392-395.
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Yan Ligang, Xu Bingxiang, Ma Zhenyeng, Zhu Yanjing , Yang Qinghua, . SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 7-SUBSTITUTED-1-ETHYL(2-FLUORO-ETHYL)-6,8-DIFLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACIDJ. Acta Pharmaceutica Sinica, 1998, 33(5): 392-395.
Citation: Yan Ligang, Xu Bingxiang, Ma Zhenyeng, Zhu Yanjing , Yang Qinghua, . SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 7-SUBSTITUTED-1-ETHYL(2-FLUORO-ETHYL)-6,8-DIFLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACIDJ. Acta Pharmaceutica Sinica, 1998, 33(5): 392-395.
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7-取代-1-乙基(2-氟乙基)-6,8-二氟-1,4-二氢-4-氧喹啉-3-羧酸的合成及抗菌活性

SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 7-SUBSTITUTED-1-ETHYL(2-FLUORO-ETHYL)-6,8-DIFLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID

    摘要
  • Abstract: Eighteen 7-substituted-1-ethyl(2-fluoroethyl)-6,8-difluoro-1,4-dihydro-4-oxoquinolone-3-carboxylic acid were designed and synthesized. The results of preliminary antibacterial test showed that most of the compounds exhibited definite activities in test against pathogenic bacteria. Especially, compound 17 and 18 showed better activities and surpassed fleroxacin when compared in vitro.

     

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