姚天荣, 陈泽乃. 包公藤的化学研究——Ⅰ.缩瞳有效成分包公藤甲素的分离和初步研究J. 药学学报, 1979, 14(12): 731-735.
引用本文: 姚天荣, 陈泽乃. 包公藤的化学研究——Ⅰ.缩瞳有效成分包公藤甲素的分离和初步研究J. 药学学报, 1979, 14(12): 731-735.
Yao Tianrong, Chen Zenai. CHEMICAL INVESTIGATION OF CHINESE MEDICINAL HERB, BAO GONG TENG I. THE ISOLATION AND PRELIMINARY STUDY ON A NEW MYOTIC CONSTITUENT, BAO GONG TENG AJ. Acta Pharmaceutica Sinica, 1979, 14(12): 731-735.
Citation: Yao Tianrong, Chen Zenai. CHEMICAL INVESTIGATION OF CHINESE MEDICINAL HERB, BAO GONG TENG I. THE ISOLATION AND PRELIMINARY STUDY ON A NEW MYOTIC CONSTITUENT, BAO GONG TENG AJ. Acta Pharmaceutica Sinica, 1979, 14(12): 731-735.

包公藤的化学研究——Ⅰ.缩瞳有效成分包公藤甲素的分离和初步研究

CHEMICAL INVESTIGATION OF CHINESE MEDICINAL HERB, BAO GONG TENG I. THE ISOLATION AND PRELIMINARY STUDY ON A NEW MYOTIC CONSTITUENT, BAO GONG TENG A

  • Abstract: The Chinese medicinal herb, Bao Gong Teng has been identified as Erycibe obtusifolia Benth. Its aqueous extract causes astrong myosis in rabbits. Two constituents have been isolated from the stem of Bao Gong Teng by column chromatographic method and are provisionally named as Bao Gong Teng A and B respectively.Bao Gong Teng A, a colorless viscous liquid, is the new effective constituent for pupillary constriction. Two stable crystalline salts, benzoate and 3,5-dinitrobenzoate were prepared and the former is being used in a pilot study for treatment of glaucoma instead of pilocarpine.Chemical and spectral data reveal that Bao Gong Teng A, C9H15O3N, may be a secondary amine. An alcoholic hydroxyl group, an acetate group and a pyrroline structure may also exist in the molecule.

     

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