Abstract: 7903, an analogue of piperine, was shown to be a potent broad spectrum anticonvulsant. In doses less than TD₅₀, it was found to be able to protect rats and mice from seizures produced by maximum electroshock (MES), metrazol, sound of electric bell (audiogenic), soclium glutamate andzinc sulfate. It also showed therapeutic effect in treating experimental epilepsy produced by intracerebral injection of ferrous sulfate in rabbits and normalized the ECOG. No protection in mice from seizures produced by picrotoxin and strychnine was found. However, the mortality of animals was reduced to various extent by pretreatment with 7903. Its action resembled diphenylhydantoin in protecting rats arid mice from MES. However, it was shown to antagonize metrazol seizure without producing convulsions when used in large doses. It also resembled phenobarbital in anticonvulsive spectrum, although it does not produce anesthesia in large doses. In addition, it was found to have sedative-hypnotic and weak tranquillizing actions, and intensify the central depressive actions of other depressants when used in combination.