Abstract: In view of the fact that the structure of substituted indanones possesses some similarity to the substituted salicylamides which have been shown to be active against schistosomiasis japonica in mice both prophylactically and therapeutocally, ninety-one compounds of substituted indanone and tetralone series were synthesized and twenty-three of them, all of which are in form of oximes, were effective in animal screening tests against Schistosoma japonicum.