哌嗪类抗肿瘤药物研究:1-(3-氯-2-羟基丙基)-4,4-二烷基哌嗪溴化物的合成

李润涛; 陈恒昌; 杨锦宗

李润涛, 陈恒昌, 杨锦宗. 哌嗪类抗肿瘤药物研究:1-(3-氯-2-羟基丙基)-4,4-二烷基哌嗪溴化物的合成J. 药学学报, 1995, 30(2): 144-149.

引用本文:

李润涛, 陈恒昌, 杨锦宗. 哌嗪类抗肿瘤药物研究:1-(3-氯-2-羟基丙基)-4,4-二烷基哌嗪溴化物的合成J. 药学学报, 1995, 30(2): 144-149.

RT Li, HC Chen , JZ Yang, . STUDIES ON ANTITUMOR DKUGS OF PIPERAZINES:SYNTHESIS OF 1-(3-CHLORO-2-HYDROXYPROPYL)- 4,4-DIALKYLPIPEKAZINE BROMIDESJ. Acta Pharmaceutica Sinica, 1995, 30(2): 144-149.

Citation:

RT Li, HC Chen , JZ Yang, . STUDIES ON ANTITUMOR DKUGS OF PIPERAZINES:SYNTHESIS OF 1-(3-CHLORO-2-HYDROXYPROPYL)- 4,4-DIALKYLPIPEKAZINE BROMIDESJ. Acta Pharmaceutica Sinica, 1995, 30(2): 144-149.

哌嗪类抗肿瘤药物研究:1-(3-氯-2-羟基丙基)-4,4-二烷基哌嗪溴化物的合成

STUDIES ON ANTITUMOR DKUGS OF PIPERAZINES:SYNTHESIS OF 1-(3-CHLORO-2-HYDROXYPROPYL)- 4,4-DIALKYLPIPEKAZINE BROMIDES

RT Li,
HC Chen , JZ Yang,

摘要

Abstract: In order to search for potential antitumor drugs of piperazincs,1-(3-chloro-2- hydroxypropyl)-4,4-dialkylpiperazine bromides(Va～g)were prepared.In preliminary toxicity and antitumor activity tests compounds Vb～d showed low toxicity,compounds Vb and Vc exhibited some inhibitory activity against carcinoma S₃₇ in rats.

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