徐懋丽, 陆见明, 雷兴翰. 血吸虫病化学治疗的研究——ⅩⅩⅩⅦ.β-(5-硝基-4-溴-2-呋喃)-及β-(4,5-二溴-2-呋喃)丙烯酰胺及其酯类的合成J. 药学学报, 1985, 20(7): 509-513.
引用本文: 徐懋丽, 陆见明, 雷兴翰. 血吸虫病化学治疗的研究——ⅩⅩⅩⅦ.β-(5-硝基-4-溴-2-呋喃)-及β-(4,5-二溴-2-呋喃)丙烯酰胺及其酯类的合成J. 药学学报, 1985, 20(7): 509-513.
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KU Mao-Li, LU Jian-Ming , LEI Xing-Han, . CHEMOTHERAPEUTIC STUDIES ON SCHISTOSOMIASIS ⅩⅩⅩⅦ. SYNTHESIS OF DERIVArIVES OF β-(5-NITRO-4-BROMO-2-FURYL)-and β-(4, 5-DIBROMO-2-FURYL) ACRYLAMIDES AND ESTERSJ. Acta Pharmaceutica Sinica, 1985, 20(7): 509-513.
Citation: KU Mao-Li, LU Jian-Ming , LEI Xing-Han, . CHEMOTHERAPEUTIC STUDIES ON SCHISTOSOMIASIS ⅩⅩⅩⅦ. SYNTHESIS OF DERIVArIVES OF β-(5-NITRO-4-BROMO-2-FURYL)-and β-(4, 5-DIBROMO-2-FURYL) ACRYLAMIDES AND ESTERSJ. Acta Pharmaceutica Sinica, 1985, 20(7): 509-513.
shu

血吸虫病化学治疗的研究——ⅩⅩⅩⅦ.β-(5-硝基-4-溴-2-呋喃)-及β-(4,5-二溴-2-呋喃)丙烯酰胺及其酯类的合成

CHEMOTHERAPEUTIC STUDIES ON SCHISTOSOMIASIS ⅩⅩⅩⅦ. SYNTHESIS OF DERIVArIVES OF β-(5-NITRO-4-BROMO-2-FURYL)-and β-(4, 5-DIBROMO-2-FURYL) ACRYLAMIDES AND ESTERS

    摘要
  • 摘要: 本文报道β-(4,5-二溴-2-呋喃)-及β-(5-硝基-4-溴-2-呋喃)丙烯酰胺及其酯类衍生物26个的合成。动物筛选结果表明;化合物Ⅲ6,Ⅲ8和Ⅲ13对感染日本血吸虫小白鼠有明显的治疗作用。化合物Ⅱ6有较明显的预防作用。

     

    Abstract: Twenty-six compounds of β-(4,5-dibromo-2-furyl)-and β-(5-nitro-4-bromo-2-furyl) acrylic amides and esters were synthesized. Among them, compounds Ⅲ6, Ⅲ8, Ⅲ13 and Ⅱ6 showed pronounced activity against Schistosoma japonicum in screening tests on mice.

     

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