吡酮酸类抗菌药物的研究——Ⅴ.1-乙基-6-氟-1,4-二氢-4-氧-7-(4-甲基-1-哌嗪)喹啉-3-羧酸新戊酰氧甲酯及其类似物的合成与抗菌活性

STUDIES ON PYRIDONECARBOXYLIC ACIDS AS ANTIBACTERIAL AGENTS V. SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF PIVALOYLOXYMETHYL 1-ETHYL-6-FLUORO-1, 4-DIHYDRO-4-OXO-7-(4-METHYL-1-PIPERAZINYL) QUINOLINE-3-CARBOXYLATE AND ITS ANALOGUES

Abstract: Synthesis and antibacterial activity of thirteen new compounds of pivaloyloxymethyl 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-methyl-1-piperazinyl)quinoline-3-carboxylate and its analogues were reported. In vivo antibacterial activities (ED₅₀) of Ⅱa, Ⅱj, Ⅱk, Ⅱl, Ⅱm were 3.64, 2.3, 4.17, 3.57, 4(mg/kg) respectively.