陈琼华, 赵永荃, 李电东. 中药大黄的综合研究 Ⅸ.大黄酸和大黄素对小鼠移植性肿瘤的影响J. 药学学报, 1966, 13(5): 363-366.
引用本文: 陈琼华, 赵永荃, 李电东. 中药大黄的综合研究 Ⅸ.大黄酸和大黄素对小鼠移植性肿瘤的影响J. 药学学报, 1966, 13(5): 363-366.
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CHEN CHIUNG-HUA CHAO YENG-CHAN LI DIEN-DONG, . Studies of Chinese Rhubarb——Ⅸ.The Effect of Rhein and Emodin on Transplantable Tumors in AnimalsJ. Acta Pharmaceutica Sinica, 1966, 13(5): 363-366.
Citation: CHEN CHIUNG-HUA CHAO YENG-CHAN LI DIEN-DONG, . Studies of Chinese Rhubarb——Ⅸ.The Effect of Rhein and Emodin on Transplantable Tumors in AnimalsJ. Acta Pharmaceutica Sinica, 1966, 13(5): 363-366.
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中药大黄的综合研究 Ⅸ.大黄酸和大黄素对小鼠移植性肿瘤的影响

Studies of Chinese Rhubarb——Ⅸ.The Effect of Rhein and Emodin on Transplantable Tumors in Animals

    摘要
  • 摘要: 本实验初步观察中药大黄中二种主要有效成分——大黄酸和大黄素,对几种小鼠移植性肿瘤的影响,结果表明,大黄素和大黄酸50毫克/公斤/天,对黑色素瘤有很明显的抑制作用,抑制率分别为76%及73%,大黄素和大黄酸分别对小鼠乳腺癌和艾氏瘤腹水型也有抑制作用,大黄酸对肉瘤180及艾氏癌皮下型的抑制作用不明显。

     

    Abstract: Emodin and rhein at a daily dosage of 50 mg/kg markedly inhibited the growth of melanoma. The percentages of inhibition were 76 and 73 respectively. Emodin and rhein also inhibited the growth of mammary carcinoma and Ehrlich carcinoma (ascitic form) respectively. Rhein showed no definite antitumor effect on sarcoma 180 and Ehrlich carcinoma(solid form).

     

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