王斌 李国强 管华诗 杨立业 童国忠. 蒙古鸦葱中的一个新三萜脂肪酸酯（英文）J. 药学学报, 2009,44(11): 1258-1261.
引用本文: 王斌 李国强 管华诗 杨立业 童国忠. 蒙古鸦葱中的一个新三萜脂肪酸酯（英文）J. 药学学报, 2009,44(11): 1258-1261.
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WANG Bin, LI Guo-Jiang, GUAN Hua-Shi, YANG Li-Ye, TONG Guo-Zhong. A new erythrodiol triterpene fatty ester from Scorzonera mongolicaJ. 药学学报, 2009,44(11): 1258-1261.
Citation: WANG Bin, LI Guo-Jiang, GUAN Hua-Shi, YANG Li-Ye, TONG Guo-Zhong. A new erythrodiol triterpene fatty ester from Scorzonera mongolicaJ. 药学学报, 2009,44(11): 1258-1261.
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蒙古鸦葱中的一个新三萜脂肪酸酯（英文）

A new erythrodiol triterpene fatty ester from Scorzonera mongolica

    摘要
  • 摘要:

    利用硅胶、Sephadex LH-20及半制备HPLC等柱色谱方法从菊科鸦葱属植物蒙古鸦葱Scorzonera mongolica Maxim.的甲醇提取物中分离得到2个化合物, 根据理化性质和光谱数据鉴定其结构分别为3β-十二酰高根二醇 (1) 和3β-十四酰高根二醇 (2)。其中, 化合物1为新化合物, 2为新天然产物。体外细胞毒活性显示化合物1和2对人肺癌细胞A-549显示一定的细胞毒活性。

     

    Abstract:

    Two erythrodiol triterpene fatty esters, 3β-dodecanoyl erythrodiol (1) and 3β-tetradecanoyl erythrodiol (2), were isolated from Scorzonera mongolica.  Their structures were elucidated on the basis of IR, MS and extensive 2D NMR spectroscopic analysis.  Compound 1 was identified to be a new compound and 2 was confirmed to be a new natural compound.  Their antitumor effects in vitro were evaluated with MTT and SRB assays, but compounds 1 and 2 only showed moderate cytotoxicities on A-549 cell line.

     

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