新抗癌有效成分海南粗榧内酯(Hainanolide)结构的研究

STUDIES ON THE STRUCTURE OF A NEW ANTITUMOR AGENT-HAINANOLIDE

摘要: 自海南粗榧树皮中分离出两种新的化合物即海南粗榧内酯和海南粗榧内酯醇,海南粗榧内酯是一种新抗癌有效成分。动物试验结果表明对L₆₁₅、S₁₈₀、Lewis肺癌P₃₈₈和L₁₂₁₀均显活性。根据X-衍射分析、核磁共振谱、红外光谱、紫外光谱、旋光光谱和质谱等证明海南粗榧内酯是一种新的结构类型的抗癌化合物,其结构式为Ⅰ。海南粗榧内酯醇的结构与海南粗榧内酯的结构很相似,其结构的研究正在进行中。

Abstract: Two new constituents, hainanolide and hainanolidol, were isolated from the bark of Cephalotaxus hainanensis Li. Hainanolide, whose structure as shown in this paper elucidated on the basis of X-ray crystallography and Spectrometric data(IR, UV, NMR, MS), was found to be active against sarcoma 180, Walker carcinosarcoma 256, Lewis lung carcinoma, L615 leukemia, P388 leukemia and L1210 leukemia. The structure of hainanolidol is still under investigation.identical with harringtonolide.