北沙参中一个新香豆素苷

A new coumarin glycoside from Glehnia littoralis

摘要: 为了研究北沙参的化学成分，本文通过大孔树脂吸附柱色谱、Sephadex LH-20及开放反相ODS柱色谱进行化合物的分离，利用多种波谱技术鉴定化合物结构。分离得到9个化合物，鉴定为：bergaptol 5-O-β-D-gentiobioside (1)、(7R，8S)-dehydrodiconiferylalcohol-4，9-di-O-β-D-glucoside (2)、橙皮素A(3)、(-)-seco-isolariciresinol 4-O-β-D-glucopyranoside (4)、白花前胡苷(5)、花椒毒酚8-O-β-D-吡喃葡糖苷(6)、5′-硫甲基腺苷(7)、腺苷(8)、色氨酸(9)。化合物1为新化合物；化合物2和7为首次从该属植物中分离得到。

Abstract: To study the chemical constituents from Glehnia littoralis, macroreticular resin column chromatography, repeated column chromatography on Sephadex LH-20 and reverse phase ODS were used to isolate the compounds whose structures were elucidated based on spectroscopic data (ESI-MS, 1D and 2D NMR). A new coumarin glycoside was isolated and identified as： bergaptol 5-O-β-D-gentiobioside (1), along with eight known compounds: (7R,8S)-dehydrodiconiferylalcohol-4,9-di-O-β-D-glucoside (2), cirtrusin A (3), (-)-seco-isolariciresinol 4-O-β-D-glucopyranoside (4), baihuaqianhuside (5), xanthotoxol 8-O-β-D-glucopyranoside (6), 5′-methylthioadenosine (7), adenosine (8), L-tryptophan (9). Compound 1 is a new coumarin glycoside,compounds 2 and 7 were isolated from this genus for the first time.