赵红, 张玉忠, 袁倬斌. 多巴胺在聚异烟酸修饰玻碳电极上的电化学行为J. 药学学报, 2002, 37(6): 454-457.
引用本文: 赵红, 张玉忠, 袁倬斌. 多巴胺在聚异烟酸修饰玻碳电极上的电化学行为J. 药学学报, 2002, 37(6): 454-457.
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ZHAO Hong, ZHANG Yu-zhong, YUAN Zhuo-bin. ELECTROCHEMICAL BEHAVIOR OF DOPAMINE AT THE POLY (ISONICOTINIC ACID) MODIFIED GLASSY CARBON ELECTRODEJ. Acta Pharmaceutica Sinica, 2002, 37(6): 454-457.
Citation: ZHAO Hong, ZHANG Yu-zhong, YUAN Zhuo-bin. ELECTROCHEMICAL BEHAVIOR OF DOPAMINE AT THE POLY (ISONICOTINIC ACID) MODIFIED GLASSY CARBON ELECTRODEJ. Acta Pharmaceutica Sinica, 2002, 37(6): 454-457.
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多巴胺在聚异烟酸修饰玻碳电极上的电化学行为

ELECTROCHEMICAL BEHAVIOR OF DOPAMINE AT THE POLY (ISONICOTINIC ACID) MODIFIED GLASSY CARBON ELECTRODE

    摘要
  • 摘要: 目的在抗坏血酸(AA)存在下,用聚异烟酸修饰电极测定神经递质多巴胺(DA)。方法用循环伏安法和示差脉冲伏安法研究DA在聚异烟酸膜修饰电极上的伏安行为。结果聚异烟酸膜修饰电极对DA有明显的电催化作用。该修饰电极使AA 的氧化峰电位负移,与DA氧化峰电位分开达204 mV,从而消除了对DA测定的干扰。DA在该修饰电极上的氧化峰电流与其浓度在1.0×10-7～2.0×10-5和2.0×10-5～1.0×10-4 mol·L-1呈良好线性关系;检测限为8.0×10-9 mol·L-1。结论聚异烟酸膜修饰电极使用寿命至少3周,可用于实际样品中DA的测定。

     

    Abstract: AIMTo study the determination of dopamine (DA) in the presence of ascobic acid (AA) using poly (isonicotinic acid) film modified electrode. METHODSThe cyclic voltammetry and differential pulse voltammetry were used to study the electrochemical behavior of DA at the poly (isonicotinic acid) film modified electrode. RESULTS The poly (isonicotinic acid) film modified electrode showed an electrocatalytic effect on DA, and shifted the oxidation of AA to negative potential. The difference between the oxidation potentials of DA and AA was 204 mV, thus,AA did not interfere with the determination of DA. The linear range between the anodic currents and DA concentration was: 1.0×10-7～2.0×10-5 and 2.0×10-5～1.0×10-4 mol·L-1. The detection limit was 8.0×10-9 mol·L-1. CONCLUSIONThe useful life period of the modified electrode is three weeks at least. The modified electrode can be used to the determination of DA in the sample.

     

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