王洪洁, 陈延镛. 红花五味子中木脂素成分的化学研究J. 药学学报, 1985, 20(11): 832-841.
引用本文: 王洪洁, 陈延镛. 红花五味子中木脂素成分的化学研究J. 药学学报, 1985, 20(11): 832-841.
WANG Hong-Jie, CHEN Yan-Yong. STUDIES OF LIGNANS FROM SCHISANDRA RUBRIFLORA RHED ET WILSJ. Acta Pharmaceutica Sinica, 1985, 20(11): 832-841.
Citation: WANG Hong-Jie, CHEN Yan-Yong. STUDIES OF LIGNANS FROM SCHISANDRA RUBRIFLORA RHED ET WILSJ. Acta Pharmaceutica Sinica, 1985, 20(11): 832-841.

红花五味子中木脂素成分的化学研究

STUDIES OF LIGNANS FROM SCHISANDRA RUBRIFLORA RHED ET WILS

  • 摘要: 从红花五味子(Schisandra rubriflora Rhed et wils)种仁的乙醇提取物中分到10个术脂素成分,其中8个为联苯环辛烯类木脂素,即五味子丙素(wuweizisu C)(1),(-)-红花五味子素(-)-rubschisandrin(2),红花五味子酯(rubschisantherin)(3),去氧五味子素(deoxyschisandrin)(4),五味子酚酯(schisanhenol acetate)(5),五味子酚乙(schisanhcnol B)(6),五味子酚(schisanhenol)(7),gomisin O(8);两个为简单木脂素,即前五味子素(pregomisin)(9),内消旋二氢癒疮木脂酸(meso-dihydroguaiaretic acid)(10)。(2),(3),(5),(6)为新木脂素,其结构经光谱分析和衍生物制备,均已确定,初步药理实验证明,(2),(6)有降低谷丙转氨酶的作用。

     

    Abstract: Ten crystalline compounds were isolated from the alcoholic extract of the kernels of Schisandra rubriflora Rhed et Wils. Eight of them were identified as dibenzocyclooctadiene lignans: wuweizisu C(1), (-)-rubschisandrin (2), rubschisantherin (3), deoxyschisandrin (4), schisanhenol acetate (5), schisanhenol B (6), schisanhenol (7) and gomisin O (8), while two of them were verified as 1,4-bis-phenyl, 2,3-dimethylbutane lignans: pregomisin (9) and meso-dihydroguaiaretic acid (10). Compounds (2), (3), (5), (6) have not been reported in the literature and their structures have been elucidated based on spectral and chemical analyses.

     

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