殷恭宽, 郭英喜, 马宝忠. 抗坏血酸注射液稳定性的研究——Ⅲ.25%抗坏血酸注射液浓度变化规律的探讨J. 药学学报, 1982, 17(5): 378-381.
引用本文: 殷恭宽, 郭英喜, 马宝忠. 抗坏血酸注射液稳定性的研究——Ⅲ.25%抗坏血酸注射液浓度变化规律的探讨J. 药学学报, 1982, 17(5): 378-381.
YIN Gong-kuan, GUO Ying-xi , MA Bao-zhong, . STUDIES ON THE STABILITY OF ASCORBIC ACID INJECTION——Ⅲ. STUDY ON THE RATE OF DEGRADATION OF 25% ASCORBIC ACID INJECTIONJ. Acta Pharmaceutica Sinica, 1982, 17(5): 378-381.
Citation: YIN Gong-kuan, GUO Ying-xi , MA Bao-zhong, . STUDIES ON THE STABILITY OF ASCORBIC ACID INJECTION——Ⅲ. STUDY ON THE RATE OF DEGRADATION OF 25% ASCORBIC ACID INJECTIONJ. Acta Pharmaceutica Sinica, 1982, 17(5): 378-381.

抗坏血酸注射液稳定性的研究——Ⅲ.25%抗坏血酸注射液浓度变化规律的探讨

STUDIES ON THE STABILITY OF ASCORBIC ACID INJECTION——Ⅲ. STUDY ON THE RATE OF DEGRADATION OF 25% ASCORBIC ACID INJECTION

  • 摘要: 探讨了25%抗坏血酸注射液在98°、90°、80℃绝氧降解的浓度变化规律,其绝氧降解都是假零级反应,降解速度常数在注射液浓度约为初浓度的85%之上与下,略有差异。以5%的注射液在98℃和12.5%的注射液在90℃的绝氧降解作对照,二者都是假一级反应,其速度常数在注射液浓度约为初浓度的75%之上与下,也略有差异。不含抗氧剂的25%抗坏血酸溶液在98℃的绝氧降解也是假零级反应。

     

    Abstract: The rate of concentration variation of 25% ascorbic acid injection in anaerobic degradation was studied at 98, 90 and 80℃. These degradations were found to be of pseudo-zero order reactions, with somewhat varying rate constants of degradation when the concentrations of the injection were greater or less than about 85% of the initial concentration. The rate of concentration variation of 5% ascorbic acid injection at 98℃ and that of 12.5% ascorbic acid injection at 90℃ in anaerobic degradations were studied for comparison. These degradations were found to be pseudo-first order reactions, with somewhat varying rate constants of degradation when the concentrations of the injection were greater or less than about 75% of the initial concentration. The anaerobic degradation at 98℃ of 25% ascorbic acid solution, not containing antioxidants, was found to be a pseudo-zero order reaction too.

     

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