徐德平 胡长鹰 王 琳 王啸春 庞自洁. 盾叶薯蓣中新甾体皂苷的研究J. 药学学报, 2009,44(1): 56-59.
引用本文: 徐德平 胡长鹰 王 琳 王啸春 庞自洁. 盾叶薯蓣中新甾体皂苷的研究J. 药学学报, 2009,44(1): 56-59.
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XU De-Beng, Hu-Chang-Ying, Wang- Lin, Wang-Chi-Chun, Long-Zi-Ji. Isolation and structure determination of steroidal saponin from Dioscorea zingiberensisJ. 药学学报, 2009,44(1): 56-59.
Citation: XU De-Beng, Hu-Chang-Ying, Wang- Lin, Wang-Chi-Chun, Long-Zi-Ji. Isolation and structure determination of steroidal saponin from Dioscorea zingiberensisJ. 药学学报, 2009,44(1): 56-59.
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盾叶薯蓣中新甾体皂苷的研究

Isolation and structure determination of steroidal saponin from Dioscorea zingiberensis

    摘要
  • 摘要: 为了研究盾叶薯蓣的水溶性化学成分, 用溶剂提取、色谱分离等方法从盾叶薯蓣的水溶液中分离到一个新甾体皂苷, 经1H NMR、13C NMR、135DEPT、HMQC、HMBC和TOCSY谱鉴定, 该化合物的结构为: (25R)-26- O-(β-D-glucopyranosyl)-furost-5-en-3b, 16, 20, 26-tetraol-22-seco-3-O-b-D-glucopyranosyl-(1→3)-b-D-glucopyranosyl- (1→4)-a-L-rhamnopyranosyl-(1→2)-b-D-glucopyranoside, 命名为zingiberenin F (1)。该化合物为一新甾体皂苷化合物, 该骨架甾体皂苷在薯蓣科中为首次报道。

     

    Abstract: To study the chemical constituents of Dioscorea zingiberensis Wright, the EtOH extract of fresh rhizomes of D. zingiberensis was concentrated and partitioned further to produce petroleum ether-, ethylacetate-, n-butanol- and water-soluble fractions.  The water-soluble fraction was subjected to column chromatography on macro resin AB-8, and the final products were obtained by repeated reversed-phase ODS and MCI gel CHP 20P column chromatography.  Structures of compounds were elucidated by 1H NMR, 13C NMR, 135DEPT, HMQC, HMBC and TOCSY spectroscopic analyses.  A new steroidal saponin was isolated, which was identified as (25R)-26-O-(β-D-glucopyranosyl)-furost-5-en-3b, 16, 20, 26-tetraol-22-seco-3-O-b-D-glucopyranosyl-(1→ 3)-b-D- glucopyranosyl-(1→ 4)-a-L-rhamnopyranosyl-(1→2)-b-D-glucopyranoside.  The compound is a novel skeletally steroidal saponin, named as zingiberenin F (1).  It was reported for the first time from D. zingiberensis Wright.

     

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