周伟澄, 忻志铭, 李炳生, 李高德, 张秀平. 碘化1-甲基-2,4-二氨基-6-(N-甲基-取代苄氨基)喹唑啉鎓的合成及其抗疟和抗肿瘤作用J. 药学学报, 1989, 24(12): 953-956.
引用本文: 周伟澄, 忻志铭, 李炳生, 李高德, 张秀平. 碘化1-甲基-2,4-二氨基-6-(N-甲基-取代苄氨基)喹唑啉鎓的合成及其抗疟和抗肿瘤作用J. 药学学报, 1989, 24(12): 953-956.
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WC Zhou, ZM Xin, BS Li, GD Li , XP Zhang, . SYNTHESIS AND ANTIMALARIAL AS WELL AS ANTITUMOR ACTIVITIES OF 1-METHYL-2,4-DIAMINO-6-(N-METHYL-SUBSTITUTED BENZYLAMION) QUINAZOLINIUM IODIDESJ. Acta Pharmaceutica Sinica, 1989, 24(12): 953-956.
Citation: WC Zhou, ZM Xin, BS Li, GD Li , XP Zhang, . SYNTHESIS AND ANTIMALARIAL AS WELL AS ANTITUMOR ACTIVITIES OF 1-METHYL-2,4-DIAMINO-6-(N-METHYL-SUBSTITUTED BENZYLAMION) QUINAZOLINIUM IODIDESJ. Acta Pharmaceutica Sinica, 1989, 24(12): 953-956.
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碘化1-甲基-2,4-二氨基-6-(N-甲基-取代苄氨基)喹唑啉鎓的合成及其抗疟和抗肿瘤作用

SYNTHESIS AND ANTIMALARIAL AS WELL AS ANTITUMOR ACTIVITIES OF 1-METHYL-2,4-DIAMINO-6-(N-METHYL-SUBSTITUTED BENZYLAMION) QUINAZOLINIUM IODIDES

    摘要
  • Abstract: Fourteen 1-methyl-2,4-diamino-6-(N-methyl-substituted benzylamino) quinazolinium iodides (Ⅱ) were synthesized by treatment of 2,4-diamino-6-substituted benzylaminoquinazolines with methyl iodide. Three compounds (Ⅱ4,7,10) were shown to produce 100% suppression on Plasmodium berghei in mice at oral dose of 20 mg/kg and Ⅱ4 was found to inhibit twice as much as methotrexate on L1210 Leukemia cells in culture.

     

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