张君才, 赵川, 宋俊峰. 流动注射双安培法测定异烟肼J. 药学学报, 2001, 36(9): 679-682.
引用本文: 张君才, 赵川, 宋俊峰. 流动注射双安培法测定异烟肼J. 药学学报, 2001, 36(9): 679-682.
shu
ZHANG Jun-cai, ZHAO Chuan, SONG Jun-feng. FLOW INJECTION BIAMPEROMETRIC ANALYSIS OF ISONIAZIDJ. Acta Pharmaceutica Sinica, 2001, 36(9): 679-682.
Citation: ZHANG Jun-cai, ZHAO Chuan, SONG Jun-feng. FLOW INJECTION BIAMPEROMETRIC ANALYSIS OF ISONIAZIDJ. Acta Pharmaceutica Sinica, 2001, 36(9): 679-682.
shu

流动注射双安培法测定异烟肼

FLOW INJECTION BIAMPEROMETRIC ANALYSIS OF ISONIAZID

    摘要
  • 摘要: 目的　建立一种快速准确的在线分析测定异烟肼的电化学方法。方法　基于不可逆电对的双安培检测原理,使用经过恒电位阳极化预处理的双铂电极,在外加电位差为0V时,通过偶合异烟肼在一支铂电极上的催化氧化和另一支铂电极上氧化铂的还原两个不可逆电对,建立了流动注射双安培检测异烟肼的新方法。结果　常用药物赋形剂、无机离子、氨基酸、维生素、蛋白质等共存物均不干扰异烟肼的测定。异烟肼的氧化电流与其浓度在1.0×10-6 - 1.0×10-4 mol·L-1 有良好的线性关系(γ=0.998,n=11)。连续8次测定1.0×10-5mol·L-1 异烟肼,电流值RSD =1 8%。结论　该方法有很高的选择性和灵敏度,且简单快速,适用于在线分析。

     

    Abstract: AIM To establish a simple, rapid, and accurate electrochemical method for on-line determination of isoniazid. METHODS Based on the flow injection biamperometry for irreversible couple system, and using two preanodized platinum electrodes with the applied potential difference of 0 V, the biamperometric method for the determination of isoniazid has been proposed by coupling the catalytic oxidation of isoniazid and the reduction of platinum oxide. RESULTS Common excipients, inorganic ions, amino acids, vitamins and proteins do not interfere with the determination. Linear relationship between current and the concentration of isoniazid is obtained in the range of 1.0×10-6 -1.0×10-4mol·L-1 (γ=0.998, n=11). The RSD of 1 8% was obtained for 8 successive determinations of 1.0×10-5mol·L-1 isoniazid. CONCLUSION The proposed method has been shown to be sensitive, selective, rapid (120 samples·h-1), and suitable for the on-line direct determination of isoniazid.

     

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