To study the chemical constituents of Cirsium setosum (Willd.) MB., 70% ethanol extract of   the aerial parts was subjected to column chromatography.  One new phenylpropanoid glycoside, sinapyl  alcohol 9-O-(E)-p-coumaroyl-4-O-β-D-glucopyanoside (1) was isolated, along with three known compounds: lycoperodine-1 (2), apigenin-7-O-(6″-(E)-p-coumaroyl)-β-D-galactopyranoside (3) and quercetin (4).  The structures were elucidated on the basis of spectral and chemical evidence.  Compound 2 was obtained from  Cirsium genus for the first time, compounds 3 and 4 were obtained from this plant for the first time.