Abstract: Traditional Chinese herbal medicine has long used Kuandong Hua (Tussilago farfara L.) in the treatment of various respiratory conditions. Recently, an ingredient of this plant (7R, 14R)-14-acetoxy-7 (2'E)-3'-methylpent-2'-enoyloxy-oplopanone, was shown to be a potent cardiovascular and respiratory stimulant and has been named Tussilagone (Tus). In conscious dogs, Tus increased peripheral resistance more thandid dopamine. The velocity of myocardial contractile element shortening, central venous pressure, coronary artery flow, and renal artery flow were not signifincantly changed. While stroke volume increased, cardiac output showed a slight but insignificant decrease due to a distinct reduction in heart rate. However, in dogs during hemorrhagic shock, Tus increased the velocity of myocardial contractile element shortenting and cardiac output significantly. Compared with dopamine, Tus exhibited stronger pressor effect associated with longer duration and was more effective in restoring the shape of deformed myocardial force-velocity loop to normal.