钩枝藤中生物碱的分离和鉴定

ISOLATION AND IDENTIFICATION OF THE ALKALOIDS FROM ANCISTROCLADUS TECTORIUS

摘要: 钩枝藤(Ancistrocladus tectorius)的总生物碱对大白鼠W-256有一定的抑制作用,从中分得三种带有萘环的四氢异喹啉生物碱结晶,晶1和晶2分别鉴定为ancistrocladine(Ⅰ)和hamatine(Ⅱ),晶3为新生物碱,命名为钩枝藤碱(ancistrocline),并推定其平面结构和部分立体关系如(Ⅲ)所示,总生物碱,晶1和晶2对小鼠肿瘤S-180和艾氏腹水瘤的抑制作用不明显,其他抗肿瘤试验还在进行中。

Abstract: The crude alkaloid extracted from the stems and twigs of Ancistrocladus tectorius (Ancistrocladaceae) was found to have inhibiting effect on Walker 256 tumor in rats. Two known alkaloids were separated and identified as ancistrocladine (Ⅰ) and hamatine (Ⅱ). Besides, a new alkaloid named ancistrocline (Ⅲ), C₂₆ H₃₁ NO₄, mp 227-228℃, α_D^{33.5^{+61.7 (CHCl₃), was separated and proved to be 5-(4, 5-dimethoxy-2-methyl-naphthyl)-1, 2, 3, 4-tetrahydro-6-hydroxy-8-methoxy-1, 3-dimethyl isoquinoline by spectral analysis. According to NMR spectral analysis, the CH₃ groups 1-and 3-positions of ancistrocline (Ⅲ) are equatorial.}}