苦玄参中一个新苦玄参酮苷的分离与结构鉴定

A new picfeltarraenone glycoside from Picria fel-terrae

摘要: 目的研究苦玄参的三萜类化学成分。方法采用大孔树脂、硅胶柱色谱纯化，经理化常数、光谱学方法鉴定结构。结果分离得到了2个三萜成分，分别鉴定为3,11,22-三羰基-16α-羟基-(20S,24)-环氧苦味素-5,23-二烯(1)和3,11,22-三羰基-16α-羟基-(20S,24)–环氧苦味素-5,23-二烯-2β-O-β-D-吡喃葡糖苷(2)。结论化合物1为已知化合物苦玄参酮I，其13CNMR数据为本文首次报导；化合物2为新三萜皂苷。

Abstract: AimTo investigate the chemical constituents from Picria fel-terrae Lour. Methods Column chromatography techniques were used to isolate the chemical constituents, physico-chemical constants and spectroscopic analysis were employed for structural elucidation. ResultsTwo triterpenoids named picfeltarraenone I (1) and picfeltarraenin XI (2) were isolated, and their structures were established to be 3,11,22-trioxo-16α-hydroxy-(20S，24)-epoxy-cucurbit-5，23- diene (1) and 3,11,22-trioxo-16α-hydroxy-(20S，24)-epoxy-cucurbit-5，23-diene-2β-O-β-D-glucopyranoside (2), respectively. ConclusionCompound 2 is a new compound, the ¹³CNMR data of compound 1 is reported for the first time.