Abstract: Huang T Y and coworkers had observed the significant schistosomicidal effect of sodium fluoroacetate in the study of carbohydrate metabolism of S. japonicum. This fact 1ed us to synthesize the fluoroacetic acid derivatives of lower toxicity. One hundred and twenty-five fluoroacetamides were prepared and submitted for animal screening tests and experimental therapy. Most of the fluoroacetamides showed prominent, antischistosomal activity and much lower toxicity than that of fluoroacetic acid. However, they were still rather toxic for clinical trial.