藏、汉族健康人对安替比林及醋氨酚代谢的种族差异

ETHNIC DIFFERENCES IN DISPOSITION OF ANTIPYRINE AND ACETAMINOPHEN BETWEEN TIBETAN AND HAN HEALTHY VOLUNTEERS

摘要: 用随机交叉设计,研究了藏、汉族健康人安替比林和醋氨酚的代谢差异。16例汉族人安替比林T_1/2为18.8±4.89h,17例藏族人为15.0±3.02h(P<0.05),汉族人安替比林清除率是1.35±0.37L·h^-1,藏族人是1.71±0.44Lt·h^-1(P<0.05)。汉族人醋氨酚T_1/2是3.1±0.86h,藏族人是3.2±1.12h(P>0.05)。实验结果表明,藏、汉族健康人安替比林的代谢有显著差异,藏族人安替比林清除率比汉族人增加了20%。藏、汉族醋氨酚的代谢无明显差异。

Abstract: The differences in disposition of antipyrine and acetaminophen between Tibetan and Han healthy volunteers were studied in a randomized crossover design. The half-life of antipyrine was found to be 18.8±4.89 h in 16 Han and 15.0±3.02 h in 17 Tibetan(P<0.05) and the clearance was 1.35±0.37 L·h^-1 in Han and 1.71±0.44 L·h^-1 in Tibetan(P<0.05). The half-life of acetaminophen was 3.1±0.86 h in Han and 3.2±1.12 h in Tibetan(P>0.05).The experimental results indicate that the disposition of antipyrine between Tibetan and Han healthy volunteers significantly differed,the clearance of antipyrine in Tibetan increased by 20%,but the disposition of acetaminophen between the two ethnic groups showed no difference.