Abstract: Several 2,3-benzopyrone analogs were synthesized for evaluating their K⁺-channel and anticancer activities. The Friedel-Crafts reaction was taken place with some replacement phenyl acetic acid or its methyl ester and vanillin as reactants in the condition of Ac₂O/ZnCl₂. All products were confirmed by means of MS and ¹H,¹³CNMR spectra. Compounds 2 and 3 showed obvious activities on the K⁺-channel and anticancer screening, while the activity of compound 5 was weak. Compound 4 was not yet tested. The primary result indicate that the potential activity of such compounds deserves further study.