丁平羽, 于德泉. 新疆藁本保肝有效成分类似物的合成研究J. 药学学报, 1996, 31(11): 817-822.
引用本文: 丁平羽, 于德泉. 新疆藁本保肝有效成分类似物的合成研究J. 药学学报, 1996, 31(11): 817-822.
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PYDing, DQYu. SYNTHESIS OF ANALOGUES OF CONISELIN,A HEPATOPROTECTIVE CONSTITUENT ISOLATED FROM CONISELIUM VAGINATUM THELLJ. Acta Pharmaceutica Sinica, 1996, 31(11): 817-822.
Citation: PYDing, DQYu. SYNTHESIS OF ANALOGUES OF CONISELIN,A HEPATOPROTECTIVE CONSTITUENT ISOLATED FROM CONISELIUM VAGINATUM THELLJ. Acta Pharmaceutica Sinica, 1996, 31(11): 817-822.
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新疆藁本保肝有效成分类似物的合成研究

SYNTHESIS OF ANALOGUES OF CONISELIN,A HEPATOPROTECTIVE CONSTITUENT ISOLATED FROM CONISELIUM VAGINATUM THELL

    摘要
  • 摘要: 从新疆藁本根茎提取物中,发现3种有降酶活性的类似结构的化合物,为进一步研究其构效关系,本文报道其中14个未见文献报道的类似物的合成。

     

    Abstract: Three compounds with high hepatoprotective activity were isolated from thealcoholic extracts of Coniselium vaginatum Thell.The relationships between structures and activitieswere studied,and fourteen analogues of them were synthesized. The structures of these syntheticpreducts were characterized by elemental analysis,1HNMR,IR and MS. Pharmacological testsshowed four of them to have some antitumour activity.Hepatoprotective activity is to be tested.

     

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