New Chemical Entities (NCEs) development is a systematic long-term project that involves multiple disciplines.  The translation research will help to build an advanced R&D system from the basic laboratory   research, preclinical studies and clinical evaluation to clinical application of drug, for the purpose of shortening the R&D cycle and accelerate the launch of new drugs.  In new drug R&D and its clinical application, drug disposition (absorption, distribution, metabolism, excretion, ADME) properties are important criteria for assessing drug-likeness of candidates.  ADME evaluation of NCEs plays an important role in the translation research throughout innovative drug R&D process.  Therefore, ADME evaluation at the early stage of drug design and development will be helpful to improve the success rate and reduce costs, and further access to safe, effective drugs.