西藏杓兰中两个新菲醌类化合物的分离与结构鉴定

Isolation and structure determination of cypritibetquinone A and B, two new phenanthraquinones from Cypripedium tibeticum

摘要: 目的研究西藏杓兰的化学成分。方法用硅胶柱色谱反复进行分离和Sephadex LH-20纯化，并通过波谱分析方法鉴定化合物结构。结果从乙酸乙酯部位分离得到两个菲醌类化合物：西藏杓兰醌A 和西藏杓兰醌B。鉴定其结构为：7-羟基-2-甲氧基-1,4-菲醌（1）；7-羟基-2,10-二甲氧基-1,4-菲醌（2）。结论西藏杓兰醌A 和西藏杓兰醌B均为新的菲醌类化合物。

Abstract: AimTo study the chemical constituents of Cypripedium tibeticum. Methods Compounds were isolated by repeated silica gel chromatography and purified on Sephadex LH-20 and structures were determined by spectral analysis. ResultsCypritibetquinones A and B were isolated from the ethyl acetate residue and their structures were determined as 7-hydroxy-2-methoxy-1,4-phenanthraquinone (1) and 7-hydroxy-2,10-dimethoxy-1,4-phenanthraquinone (2), respectively, by extensive spectral analyses. ConclusionCypritibetquinones A and B are two new phenanthraquinones.