汤丽娟, 乔培香, 张凌云. 大豆甙元—PVP共沉淀物的制备及其体外溶出度的研究J. 药学学报, 1989, 24(10): 778-782.
引用本文: 汤丽娟, 乔培香, 张凌云. 大豆甙元—PVP共沉淀物的制备及其体外溶出度的研究J. 药学学报, 1989, 24(10): 778-782.
LJ Tang, PX Qiao , LY Zhang, . PREPARATION AND DISSOLUTION STUDY OF DAIDZEIN-PVP COPREClPITATESJ. Acta Pharmaceutica Sinica, 1989, 24(10): 778-782.
Citation: LJ Tang, PX Qiao , LY Zhang, . PREPARATION AND DISSOLUTION STUDY OF DAIDZEIN-PVP COPREClPITATESJ. Acta Pharmaceutica Sinica, 1989, 24(10): 778-782.

大豆甙元—PVP共沉淀物的制备及其体外溶出度的研究

PREPARATION AND DISSOLUTION STUDY OF DAIDZEIN-PVP COPREClPITATES

  • 摘要: 以乙醇为溶媒用溶剂蒸发法制备了大豆甙元—PVP共沉淀物。X-衍射分析和偏光显微镜观察的结果表明,形成共沉淀物所需的PVP比例应大于5:1。体外溶出度试验结果表明,共沉淀物可以显著提高大豆甙元的体外溶出度。大豆甙元:PVP(1:10)的共沉淀物制成片剂后,在1 h内,90%以上的大豆甙元释放于蒸馏水或人工肠液中。

     

    Abstract: Daidzein-PVP coprecipitates were preparated by solvent evaporation method. X-ray diffraction and microscope studies indicated that the ratio of PVP should be up to 1: 5 (daidzein:PVP) to form the coprecipitates. Dissolution test, in vitro, indicated that the percent of dissolved daidzein increased remarkably by coprecipitation. The tablets made of the coprecipirates with some excipients released daidzein rapidly. Near complete release (90%) was obtained in about one hour when tested in water or simulated intestinal liquid.

     

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