吴献礼, 孔令义, 闵知大. 白花前胡丙素的结构修饰研究J. 药学学报, 2002, 37(7): 527-534.
引用本文: 吴献礼, 孔令义, 闵知大. 白花前胡丙素的结构修饰研究J. 药学学报, 2002, 37(7): 527-534.
shu
WU Xian-li, KONG Ling-yi, MIN Zhi-da. STUDIES ON STRUCTURE MODIFICATION OF (+)-PRAERUPTORIN AJ. Acta Pharmaceutica Sinica, 2002, 37(7): 527-534.
Citation: WU Xian-li, KONG Ling-yi, MIN Zhi-da. STUDIES ON STRUCTURE MODIFICATION OF (+)-PRAERUPTORIN AJ. Acta Pharmaceutica Sinica, 2002, 37(7): 527-534.
shu

白花前胡丙素的结构修饰研究

STUDIES ON STRUCTURE MODIFICATION OF (+)-PRAERUPTORIN A

    摘要
  • 摘要: 目的对白花前胡丙素［(+)-praeruptorin A］进行结构修饰,寻找活性化合物。方法首先从白花前胡(Peucedanum praeruptorum)根中分离得到白花前胡丙素,从白花前胡丙素出发,用碱水解及各种酰化反应,半合成各种结构修饰产物。结果得到18个(2～19)凯林内酯类化合物,通过IR,1HNMR和MS等方法确定其结构。结论其中14个(5～18)为新化合物,这些新化合物均有不同程度的钙离子拮抗活性,但作用强度均较白花前胡丙素弱。

     

    Abstract: AIM In order to look for new active compounds, the structure of (+)-praeruptorin A is modified. METHODS (+)-Praeruptorin A was isolated from the root of Peucedanum praeruptorum, basic hydrolysis of (+)-praeruptorin A and acyled reactions of hydrolysis product of (+)-praeruptorin A were carried out. RESULTS Eighteen compounds were semi-synthesized from (+)-praeruptorin A. CONCLUSION Fourteen compounds (5～18) among them are new compounds. Preliminary bioactivity assay indicated that the new compounds show...

     

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