冯年平, 张正行, 安登魁, 韩秀文, 黄文龙, 王广基. 7-(4-氯苄基)-7,8,13,13a-四氢小檗碱在家兔体内的代谢产物分析J. 药学学报, 2001, 36(2): 137-139.
引用本文: 冯年平, 张正行, 安登魁, 韩秀文, 黄文龙, 王广基. 7-(4-氯苄基)-7,8,13,13a-四氢小檗碱在家兔体内的代谢产物分析J. 药学学报, 2001, 36(2): 137-139.
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FENG Nian-ping, ZHANG Zheng-xing, AN Deng-kui, HAN Xiu-wen, HUAN Wen-long, WANG Guang-ji. ANALYSIS OF THE METABOLITE OF 7-(4-CHLORBENZYL)-7,8,13,13a-TETRAHYDROBERBERINE IN RABBITJ. Acta Pharmaceutica Sinica, 2001, 36(2): 137-139.
Citation: FENG Nian-ping, ZHANG Zheng-xing, AN Deng-kui, HAN Xiu-wen, HUAN Wen-long, WANG Guang-ji. ANALYSIS OF THE METABOLITE OF 7-(4-CHLORBENZYL)-7,8,13,13a-TETRAHYDROBERBERINE IN RABBITJ. Acta Pharmaceutica Sinica, 2001, 36(2): 137-139.
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7-(4-氯苄基)-7,8,13,13a-四氢小檗碱在家兔体内的代谢产物分析

ANALYSIS OF THE METABOLITE OF 7-(4-CHLORBENZYL)-7,8,13,13a-TETRAHYDROBERBERINE IN RABBIT

    摘要
  • Abstract: AIM　To explore the biotransformation of compound 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine in the rabbit. METHODS　Analyze the rabbit bile sample with HPLC, LC/MS and LC/NMR. RESULTS　A metabolite and unchanged 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine were found in the rabit bile, the metabolite was characterized and its structure was elucidated. CONCLUSION　Compound 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine is metabolized by demethylation at 10-OCH3 position.

     

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