变色马兜铃中银袋内酯乙、丙的结构测定

DETERMINATION OF THE STRUCTURES OF VERSICOLACTONE B AND VERSICOLACTONE C IN THE ROOT OF ARISTOLOCHIA VERSICOLAR S.M.HWANG

摘要: 从变色马兜铃(Aristolochia versicolar S M Hwang)的块根中分离到两个新倍半萜内酯,分别命名为银袋内酯乙(versicolactone B)和银袋内酯丙(versicolactone C)。前者分子式C₁₅H₂₀O₃,熔点135～136℃;后者分子式C₁₅H₂₂O₄,熔点181～182℃,α_D³⁶—11.4°(C,2.6,EtOH)。经光谱(UV,IR,¹H NMR,¹³SCNMR,MS)分析和化学方法证明,并经x-衍射证实,两者的结构分别为(Ⅰ)和(Ⅲ)。银袋内酯丙系一新型骨架的奠类倍半萜内酯。

Abstract: Two novel sesquiterpene lactones with the trivial names as versicolactone B and versicolactone C, were isolated from the root of Aristolochia versicolar SM H wang. Versicolactone B, C₁₅H₂₀O₃, mp 135～136℃, is a germacranolide. Versicolactone C, C₁₅H₂₂O₄, mp 181～182℃, α_D³⁶-11.4°, is a new type of sesquiterpene lactone with hydroazulene skeletone. On the basis of UV, IR, ¹H NMR, ¹³C NMR, MS and chemical reactions the structure of versicolactone B was established as(Ⅰ), and versicolactone C as(Ⅱ). The figures of (Ⅲ) obtained by x-ray crystallography confirmed it The biogenesis of versicolactone C was guessed.