甘草中三萜皂甙元的分离和结构鉴定

ISOLATION AND IDENTIFICATION OF TRITERPENE SAPOGENINS FROM GLYCYRHIZA URALENSIS FISCH.

摘要: 自乌拉尔甘草(Glycyrrhiza uralensis Fisch)根茎中提取出粗皂甙。经盐酸甲醇水解反应,柱层分离,共分离出七个皂甙元,其中四个化合物经化学方法和光谱解析,分别鉴定为甘草次酸甲酯(A),甘草内酯(c),3β,24-二羟基齐墩果-11,13(18)-二烯-30羧酸甲酯(D),24-羟基甘草次酸甲酯(F),化合物C系首次得自乌拉尔甘草中。化合物G的结构经测定为24-羟基甘草内酯,尚未见文献报道。本文报道新成分24-羟基甘草内酯的结构测定工作以及四个已知化合物的鉴定。

Abstract: Seven triterpene sapogenins were isolated from the rhizomes of Glycyrrhiza uralensis Fisch. Five of them were elucidated by spectroscopic and chemical methods as methyl glycyrrhetate(A), glabrolide(C), methyl 3β, 24-dihydroxyolean-11, 13(18)-diene-30-oate(D), methyl 24-hydroxyglycyrrhetate(F) and 24-hydroxyglabrolide(G). The last one is a new triterpene sapogenin. Studies of the chemical structure of the other two compounds (B, E) are in progress.