李芚, 刘定元, 蒙进学, 朱淑芳, 陆胜章, 高新瑜, 沈莲兰, 杨文淑. 四环素药代动力学参数的计算与血药尿药浓度相关式J. 药学学报, 1981, 16(12): 886-891.
引用本文: 李芚, 刘定元, 蒙进学, 朱淑芳, 陆胜章, 高新瑜, 沈莲兰, 杨文淑. 四环素药代动力学参数的计算与血药尿药浓度相关式J. 药学学报, 1981, 16(12): 886-891.
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Li Tun, Liu Dingyuan , Meng Jinxue Zhu Shufang Lu Shengzhang , Gao Xinyu Shen Lianlan , Yang Wenshu, . THE CALCULATION OF PHARMACOKINETIC PARAMETERS OF TETRACYCLINE AND THE FORMULA OF CORRELATION BETWEEN BLOOD LEVEL AND URINARY EXCRETIONJ. Acta Pharmaceutica Sinica, 1981, 16(12): 886-891.
Citation: Li Tun, Liu Dingyuan , Meng Jinxue Zhu Shufang Lu Shengzhang , Gao Xinyu Shen Lianlan , Yang Wenshu, . THE CALCULATION OF PHARMACOKINETIC PARAMETERS OF TETRACYCLINE AND THE FORMULA OF CORRELATION BETWEEN BLOOD LEVEL AND URINARY EXCRETIONJ. Acta Pharmaceutica Sinica, 1981, 16(12): 886-891.
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四环素药代动力学参数的计算与血药尿药浓度相关式

THE CALCULATION OF PHARMACOKINETIC PARAMETERS OF TETRACYCLINE AND THE FORMULA OF CORRELATION BETWEEN BLOOD LEVEL AND URINARY EXCRETION

    摘要
  • 摘要: 本文根据“国产四环素片生物利用度的研究”一文所发表的志愿服药者服用四环素后所测得的血药及尿药浓度数据,计算了四环素在人体的消除速度常数,半衰期、廓清率、吸收速度常数、尿药回收率、尿药排泄速度常数、表观分布容积等药代动力学参数和多次服药后的最低坪浓度。建立了血药与尿药浓度相关式。

     

    Abstract: The pharmacokinetic parameters of tetracycline were calculated by using plasma and urinary data in volunteers reported in a previous article. The formula of correlation between blood level and urinary excretion was suggested. The values of K,clr, Ka, F, Vd, and Ke were 0.06409, 65.67ml/hr 0.70,60.88%, 101 L and 0.039 respectively. The minimun plateau levels of six tablets were calculated from single dose experiment.

     

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