高博, 姚春所, 周金云, 陈若芸, 方唯硕, . 木立芦荟中BACE抑制活性成分的研究J. 药学学报, 2006, 41(10): 1000-1003.
引用本文: 高博, 姚春所, 周金云, 陈若芸, 方唯硕, . 木立芦荟中BACE抑制活性成分的研究J. 药学学报, 2006, 41(10): 1000-1003.
shu
GAO Bo, YAO Chun-suo, ZHOU Jin-yun, CHEN Ruo-yun, FANG Wei-shuo, . Active constituents from Aloe arborescens as BACE inhibitorsJ. Acta Pharmaceutica Sinica, 2006, 41(10): 1000-1003.
Citation: GAO Bo, YAO Chun-suo, ZHOU Jin-yun, CHEN Ruo-yun, FANG Wei-shuo, . Active constituents from Aloe arborescens as BACE inhibitorsJ. Acta Pharmaceutica Sinica, 2006, 41(10): 1000-1003.
shu

木立芦荟中BACE抑制活性成分的研究

Active constituents from Aloe arborescens as BACE inhibitors

    摘要
  • 摘要: 目的从木立芦荟(Aloe arborescens)中寻找新的BACE(β-分泌酶)抑制活性成分。方法用硅胶正相色谱及反相色谱技术进行活性成分的分离纯化，根据理化性质、光谱资料进行结构鉴定。结果从木立芦荟95%乙醇提取物的乙酸乙酯部分和正丁醇部分，分离得到了8个化合物：异丁酰基芦荟宁A(1)，芦荟宁A(2)，芦荟大黄素(3)，(E)-2-acetonyl-8-(2′-O-feruloxyl)-β-D-glucopyranosyl-7-methoxy-5-methyl-chromone (4)，7-O-methyl aloeresin A (5)，芦荟苷A(6)，elgonica-dimer A (7)和elgonica-dimer B (8)。结论化合物1为新化合物，化合物4为首次从该植物中分离得到。活性测试结果表明，化合物2，4，5，6对BACE有一定的抑制活性。

     

    Abstract: AimTo seek for new components as BACE inhibitors from Aloe arborescens. Methods The chemical constituents were isolated by chromatographic methods and their structures were elucidated on the basis of spectral analysis. ResultsEight compounds were isolated and their structures identified as 6′-O-isobutyryl aloenin A (1), aloenin A (2), aloe-emodin (3), (E)-2-acetonyl-8-(2′-O-feruloxyl)-β-D-glucopyranosyl-7-methoxy-5-methyl-chromone (4), 7-O-methylaloeresin A (5), babarloin A (6), elgonica-dimer A (7), and elgonica-dimer B (8), separately. ConclusionCompound 1 is a new compound, and compound 4 was isolated from A.arborescens for the first time. Pharmacological tests indicated that 2, 4, 5 and 6 have moderate inhibitory active on BACE.

     

    • HTML全文
    • 参考文献(0)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回