藏药薰倒牛的活性物质研究

STUDIES ON THE ACTIVE CONSTITUENTS OF TIBETAN HERB BIEBERSTEINIA HETEROSTEMON MAXIM.

摘要: 从植物藏药薰倒牛(BiebersteiniaheterostemonMaxim.)中首次分离得7个化合物,经化学方法和光谱解析鉴定为:β-谷甾醇(Ⅰ)、胡萝卜甙(Ⅱ)、伞形花内酯(Ⅲ)、5,7,3′-三羟基-8,4′,5′-三甲氧基黄酮(Ⅳ)、木犀草素-7-葡萄糖甙(Ⅴ)、槲皮素-7-葡萄糖甙(Ⅵ)和N-3-甲基-2-丁烯基脲(Ⅶ)。其中Ⅳ和Ⅶ是二个新的天然产物。药理实验表明化合物Ⅶ有镇痛、降压等活性。

Abstract: Seven compounds have been isolated from the Tibetan herb Biebersteinia heterostemon Maxim.On basis of IR ,UV ,NMR ,MS spectral data and chemical methods,their structures wereidentified as :β-sitosterol(Ⅰ) ,daucosterol(Ⅱ), umbelliferone(Ⅲ),5,7,3′-trihydroxy-8,4′,5′-trimethoxyflavone (Ⅳ),glucoluteolin(Ⅴ),quercimeritrin(Ⅵ)and N-3-methyl-2-butenyl urea(Ⅶ).Compounds Ⅳ and Ⅶ are two new natural products.Compound Ⅶ is an active constituent.In pharmacological tests it showed some hypotensive,analgesic and immunity stimulating effects.