P-矩阵分光光度法同时测定复方降压片中六种组分的含量

P-MATRIX SPECTROPHOTOMETRIC DETERMINATION OF 6 COMPONENTS CONTAINED IN COMPOUND RESERPINE TABLETS

摘要: 本文应用P-矩阵分光光度法同时测定十组分的复方降压片中维生素B₁、维生素B₆、利眠宁、盐酸异丙嗪、硫酸双肼肽嗪及氢氯噻嗪等六种组分的含量,并应用“条件数”原理来选择最佳测定波长,同时就实验误差,测定点数、“条件数”、组分浓度对处方量的偏差等因素对该法计算结果的影响进行了较为深入的探讨。被测组分的平均回收率均在97～10?%范围之内,变异系数(CV%)均小于或等于9.5(n=11)。

Abstract: P-matrix method has been developed for the simultaneous determination of vitamin B₁, vitamin B₆, chlordiazepoxide, dihydralazins sulfate, promethazine hydrochloride and hydrochlorothiazide contained in compound reserpine tablets consisting of 10 components.The optimal wavelength for measurement was successfully selected based on the principle of condition number. The influence of experimental error, number of wavelength and condition number deviation of component concentration from formula were discussed. The average recoveries varied from 97～103% with CV≤9.5% (n=11).