王欣, 王洪庆, 康洁, 刘超, 陈若芸. 桑葚的化学成分研究J. 药学学报, 2014,49(4): 504-506.
引用本文: 王欣, 王洪庆, 康洁, 刘超, 陈若芸. 桑葚的化学成分研究J. 药学学报, 2014,49(4): 504-506.
WANG Xin, WANG Hong-qing, KANG Jie, LIU Chao, CHEN Ruo-yun. Studies on chemical constituents from fruits of Morus alba L.J. Acta Pharmaceutica Sinica, 2014,49(4): 504-506.
Citation: WANG Xin, WANG Hong-qing, KANG Jie, LIU Chao, CHEN Ruo-yun. Studies on chemical constituents from fruits of Morus alba L.J. Acta Pharmaceutica Sinica, 2014,49(4): 504-506.

桑葚的化学成分研究

Studies on chemical constituents from fruits of Morus alba L.

  • 摘要: 采用硅胶、Sephadex LH-20、RP-C18等色谱方法从桑葚95% 乙醇提取物中分离得到15个化合物,根据化合物的波谱数据分别鉴定为1-5-(2-formlfuryl)methyldihydrogen 2-hydroxypropane-1,2,3-tricarboxylate 2,3-diethyl ester(1)、1-2-(furan-2-yl)-2-oxoethyl pyrrolidin-2-one(2)、divaricataester A(3)、methyl 1-2-(furan-2-yl)- 2-oxoethyl-5-oxopyrrolidine-2-carboxylate(4)、1-2-(furan-2-yl)-2-oxoethyl-5-oxopyrrolidine-2-carboxylic acid(5)、焦谷氨酸(6)、焦谷氨酸乙酯(7)、3-O-咖啡酰奎宁酸甲酯(8)、3-O-咖啡酰奎宁酸乙酯(9)、5-O-咖啡酰奎宁酸甲酯(10)、5-O-咖啡酰奎宁酸乙酯(11)、4-O-咖啡酰奎宁酸甲酯(12)、4-O-咖啡酰奎宁酸乙酯(13)、4-O-咖啡酰奎宁酸(14)和3-O-咖啡酰奎宁酸(15)。其中化合物1为新化合物,化合物114均为首次从桑属植物中分离得到。

     

    Abstract: Chemical investigation of fruits of Mours alba L. lead to the isolation of fifteen compounds by various chromatographies such as silica gel, Sephadex LH-20, RP-C18 column chromatography. Their structures were determined to be: 1-5-(2-formlfuryl) methyl dihydrogen 2-hydroxypropane-1, 2, 3-tricarboxylate 2, 3-diethyl ester (1), 1-2-(furan-2-yl)-2-oxoethyl pyrrolidin-2-one (2), divaricataester A (3), methyl 1-2-(furan-2-yl)-2- oxoethyl-5-oxopyrrolidine-2-carboxylate (4), 1-2-(furan-2-yl)-2-oxoethyl-5-oxopyrrolidine-2-carboxylic acid (5), L-pyroglutamic acid (6), L-pyroglutamic acid ethyl ester (7), 3-O-caffeoylquinic acid methyl ester (8), 3-O- caffeoylquinic acid ethyl ester (9), 5-O-caffeoylquinic acid methyl ester (10), 5-O-caffeoylquinic acid ethyl ester (11), 4-O-caffeoylquinic acid methyl ester (12), 4-O-caffeoylquinic acid methyl ester (13), 4-O-caffeoylquinic acid (14), 3-O-caffeoylquinic acid (15), respectively, based on the spectral analysis such as NMR, MS etc. Compounds 1-14 were isolated from this genus for the first time, among which 1 was a new compound.

     

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