乙酰丹酚酸 A──一种新型血栓素合成酶抑制剂

吁文贵, 徐理纳. 乙酰丹酚酸 A──一种新型血栓素合成酶抑制剂J. 药学学报, 1997, 32(6): 467-469.

引用本文:

吁文贵, 徐理纳. 乙酰丹酚酸 A──一种新型血栓素合成酶抑制剂J. 药学学报, 1997, 32(6): 467-469.

WG Yu, LN Xu. ACETYLSALVIANOLIC ACID A──A NEW THROMBOXANE SYNTHETASE INHIBITORJ. Acta Pharmaceutica Sinica, 1997, 32(6): 467-469.

Citation:

WG Yu, LN Xu. ACETYLSALVIANOLIC ACID A──A NEW THROMBOXANE SYNTHETASE INHIBITORJ. Acta Pharmaceutica Sinica, 1997, 32(6): 467-469.

ACETYLSALVIANOLIC ACID A──A NEW THROMBOXANE SYNTHETASE INHIBITOR

Abstract: With radio thin layer chromatography and autoradiogram, the effect of acetylsalvianolic acid A (ASAA) on ¹⁴C-arachidonic metabolism by platelets was studied in vitro. ASAA was found to enhance the formation of PGE-2 and PGF_2α remarkably while inhibiting the formation of TXB₂. However, it showed no effect on the formation of 12-HETE and arachidonic utility rate. Therefore, we deduce that ASAA may be a thromboxane synthetase inhibitor.

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